Hyperthermic Application of Manganese Doped Cobalt Ferrite Nanoparticles in Therapeutic Treatment of Cancer

¹Department of Physics, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh
²Departments of Chemistry and Physics, Gono Bishwabidyalay, Savar, Dhaka, Bangladesh
³Military Institute of Science and Technology, Mirpur Cantonment, Dhaka-1216, Bangladesh
*Corresponding Author: Dr. Md. Ziaul Ahsan, Military Institute of Science and Technology, Mirpur Cantonment, Dhaka-1216, Bangladesh, Phone: 01769760880; Email: [email protected]

Received Date: June 10, 2024

Publication Date: July 25, 2024

Citation: Ahsan MZ, et al. (2024). Hyperthermic Application of Manganese Doped Cobalt Ferrite Nanoparticles in Therapeutic Treatment of Cancer. Material Science. 6(2):29.

Copyright: Ahsan MZ, et al. © (2024).

ABSTRACT

The results on the dynamic response of magnetic behavior, associated with the mechanism of producing heat, of manganese doped cobalt ferrite nanoparticles with the composition formula Co_1-xMn_xFe₂O₄ (0.125≤x≤0.5) are reported in this research article to highlight its potential medical related applications, in particular hyperthermic application in therapeutic approach for tumor cancer treatment. The samples were prepared through the solid-state reaction route using the ball milling technique. The X-ray diffraction profile demonstrates a rising trend in crystallite size (64.02nm – 67.17nm) with the Mn content. The non-responsive of the imaginary part of complex permeability with increasing frequency represents a constant conversion of electromagnetic energy into heat. The magnetic modulus analysis examined the correlation between structural/microstructural and magnetic relaxation loss. The peaks in the spectrum of the imaginary part correspond to the resonance frequency that follows the increasing trend of crystallite size with increasing Mn content and entails the absorption of magnetic energy from the alternating magnetic field that heats the material, produced by the mechanism of magnetic relaxation loss. Thus, this heating energy becomes tunable with the Mn content and marks the sample suitable to be used in magnetic induction hyperthermia therapeutic treatment of breast cancer as well as other tumor cancer after optimizing the required temperature and functionalizing with the necessary biocompatible materials, which is alleged as its novelty of this study because of fostering this relaxation magnetic loss as an alternative use in medical fields.

Keywords: Manganese dopped Cobalt ferrite, Permeability, Magnetic modulus, Hyperthermia